To effectively treat acne-prone skin, Obagi recommends using both salicylic acid and benzoyl peroxide as part of a complete and balanced acne treatment regimen. This has shown to be highly effective, with benzoyl peroxide actively targeting bacteria, while salicylic acid gently exfoliates and soothe skin. *Item is sold separately from the CLENZIderm M.D. Acne Therapeutic System.