?Keeffe?s Working Hands Hand Cream is a concentrated hand cream that heals, relieves and repairs extremely dry, cracked hands. When used daily, O?Keeffe?s Working Hands is clinically proven to Instantly boost moisture levels, Create a protective layer on the skins surface, and Help prevent further moisture loss. It is safe and effective for people with diabetes. Why does O'Keeffe's work? The skin's natural barrier can be damaged, causing dry, cracked skin. O'Keeffe's products are specially formulated to create a protective barrier on the skin's surface that locks in moisture and keeps your skin hydrated.