O'Keeffe's working hands cream, 7 oz tube. O'Keeffe's working hands hand cream is a concentrated hand cream that heals, relieves, and repairs extremely dry, cracked hands. When used daily, O'Keeffe's working hands are clinically proven to instantly boost moisture levels. Working hands create a protective layer on the skin's surface that helps prevent further moisture loss. Working hands is safe and effective for people with diabetes.