Coffin Siris syndrome is very rare genetic syndrome.THE TOTAL NUMBER OF THE REPORTED PATIENTS WITH COFFIN SIRIS SYNDROME IS 169. Coffin Siris syndrome has been reported only once in Iraq. The first Iraqi patient with Coffin Siris syndrome (Al Mosawi AJ,2006) was also the first patient in the Arab. The main aim of this book is to describe the second case of this syndrome in Iraq which is also the case number 170 in the world. The book also describes the historic documentation of the syndrome in the literature.